Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.9
USERS' SCORE
Good
Based on 3 Reviews
8.2
Supplement Facts
Serving Size: 5 Drops
Amount Per Serving
%DV
Vitamin D (as cholecalciferol)
10 mcg (400 IU)
100%
L.reuteriDSM 17938(L. reuteriProtectis®)
100 million CFU
†
Top Medical Research Studies
7
Vitamin D's role in heart health
We examined how low levels of vitamin D (Vit D) could impact the severity of heart disease, specifically looking at myocardial ischemia. Our study involved two hundred patients who underwent myocardial perfusion imaging at Namazi Hospital in Shiraz, Iran, in 2019. We assessed both the severity of ischemia in patients and their vitamin D levels.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
Read More
8
We explored the relationship between vitamin D deficiency and heart disease, particularly how it interacts with a condition called hyperhomocysteinemia, which is known to promote heart issues. In our study, we examined both animal models (rats fed a diet to induce hyperhomocysteinemia) and heart cells under lab conditions to understand this interaction better.
Our findings revealed that hyperhomocysteinemia significantly lowered levels of vitamin D, specifically 1,25(OH)D, in the blood and heart tissues. We also noted an increase in the expression of an enzyme (CYP24A1) that breaks down vitamin D, indicating a disruption in its availability. Moreover, the presence of elevated homocysteine was linked to a decrease in vitamin D receptor (VDR) expression in heart tissues, complicating the heart's ability to respond to vitamin D’s effects.
By manipulating levels of VDR, we demonstrated that reducing VDR led to more heart cell growth, which is a sign of heart hypertrophy. Conversely, when VDR was overexpressed, we observed a decrease in hypertrophy, showing that vitamin D plays a protective role against heart enlargement during hyperhomocysteinemia. Additionally, a specific microRNA (miR-125b-5p) was found to repress VDR and contribute to heart cell growth, highlighting the complex regulatory network involved.
Our study concluded that vitamin D deficiency and reduced VDR contribute to heart issues associated with high levels of homocysteine by activating harmful cellular pathways. This underscores the potential significance of monitoring and supporting vitamin D levels, especially in individuals suffering from hyperhomocysteinemia.
Our findings revealed that hyperhomocysteinemia significantly lowered levels of vitamin D, specifically 1,25(OH)D, in the blood and heart tissues. We also noted an increase in the expression of an enzyme (CYP24A1) that breaks down vitamin D, indicating a disruption in its availability. Moreover, the presence of elevated homocysteine was linked to a decrease in vitamin D receptor (VDR) expression in heart tissues, complicating the heart's ability to respond to vitamin D’s effects.
By manipulating levels of VDR, we demonstrated that reducing VDR led to more heart cell growth, which is a sign of heart hypertrophy. Conversely, when VDR was overexpressed, we observed a decrease in hypertrophy, showing that vitamin D plays a protective role against heart enlargement during hyperhomocysteinemia. Additionally, a specific microRNA (miR-125b-5p) was found to repress VDR and contribute to heart cell growth, highlighting the complex regulatory network involved.
Our study concluded that vitamin D deficiency and reduced VDR contribute to heart issues associated with high levels of homocysteine by activating harmful cellular pathways. This underscores the potential significance of monitoring and supporting vitamin D levels, especially in individuals suffering from hyperhomocysteinemia.
Read More
7
We set out to understand how vitamin D levels relate to diastolic function in patients experiencing acute coronary syndrome (ACS). Our study included 117 patients who were monitored before their discharge from the hospital. We used echocardiography to assess their heart function, specifically looking at how well their hearts could relax after beating—a key indicator of heart health.
The results revealed that those with low vitamin D levels tended to have more significant diastolic dysfunction. For instance, measures like the isovolumetric relaxation time (IVRT) and the E/e' ratio were notably higher in patients with lower vitamin D. Further analysis showed that vitamin D levels could predict the likelihood of developing diastolic dysfunction, making it an independent risk factor.
Overall, our findings suggest that vitamin D deficiency may contribute negatively to heart function in individuals with ACS. Highlighting the importance of maintaining adequate vitamin D levels, this research could encourage further exploration of vitamin D as a potential target for improving heart health in at-risk populations.
The results revealed that those with low vitamin D levels tended to have more significant diastolic dysfunction. For instance, measures like the isovolumetric relaxation time (IVRT) and the E/e' ratio were notably higher in patients with lower vitamin D. Further analysis showed that vitamin D levels could predict the likelihood of developing diastolic dysfunction, making it an independent risk factor.
Overall, our findings suggest that vitamin D deficiency may contribute negatively to heart function in individuals with ACS. Highlighting the importance of maintaining adequate vitamin D levels, this research could encourage further exploration of vitamin D as a potential target for improving heart health in at-risk populations.
Read More
Most Useful Reviews
9
Colic relief achieved
My baby isn’t colicky anymore thanks to BioGaia baby drops. Money well spent!
Read More
6
Effective for skin
4 people found this helpful
Best probiotic for my baby. My doctor recommended this, and while the initial impact on his skin wasn’t great, there was noticeable improvement after we resumed giving it to him every morning. During the two-week wait for the second order, his eczema worsened. After restarting the Biogaia, his skin improved, and he can now poo every day. I know this works for him and stocked up during sales.
Read More
7.5
Great benefit noted
5 people found this helpful
Excellent quality. The ingredients are natural. The taste is acceptable for Nono. A small size lasts about two months. The packaging is excellent. The benefit has significantly relieved me of colic and gases. Nono is nearly two months old, and I use this nutritional supplement with a serving of 5 drops daily. Improvement noted!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.9
- All Researches
8
We conducted a study to explore how vitamin D3, combined with SGLT2 inhibitors, could influence heart health in hypertensive obese patients suffering from obstructive sleep apnea (OSA). This combination therapy was assessed for its effects on various health parameters and the quality of life of the participants.
In our investigation, patients were randomly assigned to receive either Dapagliflozin, vitamin D3, a combination of both, or no treatment at all over 16 weeks. We closely looked at measurements such as weight, blood pressure, blood sugar levels, liver health, and heart function among others.
Our findings were promising, revealing beneficial effects of combining vitamin D3 with SGLT2 inhibitors. Participants who received this combination reported improvements in their cardio-metabolic health and overall quality of life, suggesting a potential new approach to managing heart disease in this specific group of patients.
It is important to note that while this study highlights the synergistic benefits of vitamin D3 and SGLT2 inhibitors, the isolated impact of vitamin D itself on heart disease remains somewhat unclear. This complexity underscores the need for further research to fully understand vitamin D's role in cardiovascular health.
In our investigation, patients were randomly assigned to receive either Dapagliflozin, vitamin D3, a combination of both, or no treatment at all over 16 weeks. We closely looked at measurements such as weight, blood pressure, blood sugar levels, liver health, and heart function among others.
Our findings were promising, revealing beneficial effects of combining vitamin D3 with SGLT2 inhibitors. Participants who received this combination reported improvements in their cardio-metabolic health and overall quality of life, suggesting a potential new approach to managing heart disease in this specific group of patients.
It is important to note that while this study highlights the synergistic benefits of vitamin D3 and SGLT2 inhibitors, the isolated impact of vitamin D itself on heart disease remains somewhat unclear. This complexity underscores the need for further research to fully understand vitamin D's role in cardiovascular health.
Read More
8
We explored the relationship between vitamin D deficiency and heart disease, particularly how it interacts with a condition called hyperhomocysteinemia, which is known to promote heart issues. In our study, we examined both animal models (rats fed a diet to induce hyperhomocysteinemia) and heart cells under lab conditions to understand this interaction better.
Our findings revealed that hyperhomocysteinemia significantly lowered levels of vitamin D, specifically 1,25(OH)D, in the blood and heart tissues. We also noted an increase in the expression of an enzyme (CYP24A1) that breaks down vitamin D, indicating a disruption in its availability. Moreover, the presence of elevated homocysteine was linked to a decrease in vitamin D receptor (VDR) expression in heart tissues, complicating the heart's ability to respond to vitamin D’s effects.
By manipulating levels of VDR, we demonstrated that reducing VDR led to more heart cell growth, which is a sign of heart hypertrophy. Conversely, when VDR was overexpressed, we observed a decrease in hypertrophy, showing that vitamin D plays a protective role against heart enlargement during hyperhomocysteinemia. Additionally, a specific microRNA (miR-125b-5p) was found to repress VDR and contribute to heart cell growth, highlighting the complex regulatory network involved.
Our study concluded that vitamin D deficiency and reduced VDR contribute to heart issues associated with high levels of homocysteine by activating harmful cellular pathways. This underscores the potential significance of monitoring and supporting vitamin D levels, especially in individuals suffering from hyperhomocysteinemia.
Our findings revealed that hyperhomocysteinemia significantly lowered levels of vitamin D, specifically 1,25(OH)D, in the blood and heart tissues. We also noted an increase in the expression of an enzyme (CYP24A1) that breaks down vitamin D, indicating a disruption in its availability. Moreover, the presence of elevated homocysteine was linked to a decrease in vitamin D receptor (VDR) expression in heart tissues, complicating the heart's ability to respond to vitamin D’s effects.
By manipulating levels of VDR, we demonstrated that reducing VDR led to more heart cell growth, which is a sign of heart hypertrophy. Conversely, when VDR was overexpressed, we observed a decrease in hypertrophy, showing that vitamin D plays a protective role against heart enlargement during hyperhomocysteinemia. Additionally, a specific microRNA (miR-125b-5p) was found to repress VDR and contribute to heart cell growth, highlighting the complex regulatory network involved.
Our study concluded that vitamin D deficiency and reduced VDR contribute to heart issues associated with high levels of homocysteine by activating harmful cellular pathways. This underscores the potential significance of monitoring and supporting vitamin D levels, especially in individuals suffering from hyperhomocysteinemia.
Read More
7
Vitamin D's role in heart health
We examined how low levels of vitamin D (Vit D) could impact the severity of heart disease, specifically looking at myocardial ischemia. Our study involved two hundred patients who underwent myocardial perfusion imaging at Namazi Hospital in Shiraz, Iran, in 2019. We assessed both the severity of ischemia in patients and their vitamin D levels.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
Read More
7
We explored the connection between vitamin D and heart disease, focusing on its effects in a specific scenario: the response of H9c2 cardiomyoblasts to angiotensin II (Ang II), a substance often involved in heart issues. In our study, we exposed these heart cells to Ang II alone and in combination with vitamin D while also manipulating the activity of a protein called SIRT1.
Our findings showed that while vitamin D significantly reduced the hypertrophy caused by Ang II—meaning it helped to keep the cells from growing excessively—this effect didn’t rely on SIRT1. Interestingly, when SIRT1 was blocked, vitamin D lost its ability to protect the cells from decreased viability, indicating that SIRT1 is essential for vitamin D’s pro-survival benefits but not for its anti-hypertrophic effects.
This suggests that vitamin D has a complex role in heart health. While it can prevent excessive cell growth, it needs SIRT1 to boost cell survival. Therefore, strategies that enhance SIRT1 activity alongside vitamin D could offer a promising path to tackle issues like cardiac hypertrophy and heart failure.
Our findings showed that while vitamin D significantly reduced the hypertrophy caused by Ang II—meaning it helped to keep the cells from growing excessively—this effect didn’t rely on SIRT1. Interestingly, when SIRT1 was blocked, vitamin D lost its ability to protect the cells from decreased viability, indicating that SIRT1 is essential for vitamin D’s pro-survival benefits but not for its anti-hypertrophic effects.
This suggests that vitamin D has a complex role in heart health. While it can prevent excessive cell growth, it needs SIRT1 to boost cell survival. Therefore, strategies that enhance SIRT1 activity alongside vitamin D could offer a promising path to tackle issues like cardiac hypertrophy and heart failure.
Read More
7
We set out to understand how vitamin D levels relate to diastolic function in patients experiencing acute coronary syndrome (ACS). Our study included 117 patients who were monitored before their discharge from the hospital. We used echocardiography to assess their heart function, specifically looking at how well their hearts could relax after beating—a key indicator of heart health.
The results revealed that those with low vitamin D levels tended to have more significant diastolic dysfunction. For instance, measures like the isovolumetric relaxation time (IVRT) and the E/e' ratio were notably higher in patients with lower vitamin D. Further analysis showed that vitamin D levels could predict the likelihood of developing diastolic dysfunction, making it an independent risk factor.
Overall, our findings suggest that vitamin D deficiency may contribute negatively to heart function in individuals with ACS. Highlighting the importance of maintaining adequate vitamin D levels, this research could encourage further exploration of vitamin D as a potential target for improving heart health in at-risk populations.
The results revealed that those with low vitamin D levels tended to have more significant diastolic dysfunction. For instance, measures like the isovolumetric relaxation time (IVRT) and the E/e' ratio were notably higher in patients with lower vitamin D. Further analysis showed that vitamin D levels could predict the likelihood of developing diastolic dysfunction, making it an independent risk factor.
Overall, our findings suggest that vitamin D deficiency may contribute negatively to heart function in individuals with ACS. Highlighting the importance of maintaining adequate vitamin D levels, this research could encourage further exploration of vitamin D as a potential target for improving heart health in at-risk populations.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Colic relief achieved
My baby isn’t colicky anymore thanks to BioGaia baby drops. Money well spent!
Read More
6
Effective for skin
4 people found this helpful
Best probiotic for my baby. My doctor recommended this, and while the initial impact on his skin wasn’t great, there was noticeable improvement after we resumed giving it to him every morning. During the two-week wait for the second order, his eczema worsened. After restarting the Biogaia, his skin improved, and he can now poo every day. I know this works for him and stocked up during sales.
Read More
7.5
Great benefit noted
5 people found this helpful
Excellent quality. The ingredients are natural. The taste is acceptable for Nono. A small size lasts about two months. The packaging is excellent. The benefit has significantly relieved me of colic and gases. Nono is nearly two months old, and I use this nutritional supplement with a serving of 5 drops daily. Improvement noted!
Read More
Frequently Asked Questions
9
Colic relief achieved
My baby isn’t colicky anymore thanks to BioGaia baby drops. Money well spent!
6
Effective for skin
4 people found this helpful
Best probiotic for my baby. My doctor recommended this, and while the initial impact on his skin wasn’t great, there was noticeable improvement after we resumed giving it to him every morning. During the two-week wait for the second order, his eczema worsened. After restarting the Biogaia, his skin improved, and he can now poo every day. I know this works for him and stocked up during sales.
7.5
Great benefit noted
5 people found this helpful
Excellent quality. The ingredients are natural. The taste is acceptable for Nono. A small size lasts about two months. The packaging is excellent. The benefit has significantly relieved me of colic and gases. Nono is nearly two months old, and I use this nutritional supplement with a serving of 5 drops daily. Improvement noted!
4
We investigated the relationship between vitamin D levels and exercise capacity in adults with congenital heart disease (CHD). In our study, we examined 55 CHD patients and 55 healthy peers, looking at how their vitamin D levels correlated with various health metrics, including their ability to exercise.
Despite the common concern about vitamin D deficiency, we found that levels were similar between CHD patients and healthy controls, though both groups exhibited high rates of vitamin D insufficiency. While vitamin D levels didn't significantly correlate with many factors such as age, body mass index, or blood pressure, we did observe a noteworthy connection between vitamin D levels and exercise performance.
Specifically, lower vitamin D levels were linked to reduced exercise capacity among CHD patients. This suggests that while vitamin D may not drastically affect heart disease outcomes on its own, it plays a role in physical performance. The findings highlight the need for further research into whether supplementing vitamin D might enhance exercise capacity in individuals with vitamin D insufficiency and CHD.
Despite the common concern about vitamin D deficiency, we found that levels were similar between CHD patients and healthy controls, though both groups exhibited high rates of vitamin D insufficiency. While vitamin D levels didn't significantly correlate with many factors such as age, body mass index, or blood pressure, we did observe a noteworthy connection between vitamin D levels and exercise performance.
Specifically, lower vitamin D levels were linked to reduced exercise capacity among CHD patients. This suggests that while vitamin D may not drastically affect heart disease outcomes on its own, it plays a role in physical performance. The findings highlight the need for further research into whether supplementing vitamin D might enhance exercise capacity in individuals with vitamin D insufficiency and CHD.
7
Vitamin D's role in heart health
We examined how low levels of vitamin D (Vit D) could impact the severity of heart disease, specifically looking at myocardial ischemia. Our study involved two hundred patients who underwent myocardial perfusion imaging at Namazi Hospital in Shiraz, Iran, in 2019. We assessed both the severity of ischemia in patients and their vitamin D levels.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
7
We set out to understand how vitamin D levels relate to diastolic function in patients experiencing acute coronary syndrome (ACS). Our study included 117 patients who were monitored before their discharge from the hospital. We used echocardiography to assess their heart function, specifically looking at how well their hearts could relax after beating—a key indicator of heart health.
The results revealed that those with low vitamin D levels tended to have more significant diastolic dysfunction. For instance, measures like the isovolumetric relaxation time (IVRT) and the E/e' ratio were notably higher in patients with lower vitamin D. Further analysis showed that vitamin D levels could predict the likelihood of developing diastolic dysfunction, making it an independent risk factor.
Overall, our findings suggest that vitamin D deficiency may contribute negatively to heart function in individuals with ACS. Highlighting the importance of maintaining adequate vitamin D levels, this research could encourage further exploration of vitamin D as a potential target for improving heart health in at-risk populations.
The results revealed that those with low vitamin D levels tended to have more significant diastolic dysfunction. For instance, measures like the isovolumetric relaxation time (IVRT) and the E/e' ratio were notably higher in patients with lower vitamin D. Further analysis showed that vitamin D levels could predict the likelihood of developing diastolic dysfunction, making it an independent risk factor.
Overall, our findings suggest that vitamin D deficiency may contribute negatively to heart function in individuals with ACS. Highlighting the importance of maintaining adequate vitamin D levels, this research could encourage further exploration of vitamin D as a potential target for improving heart health in at-risk populations.
7
We investigated the complex relationship between magnesium levels, vitamin D concentrations, and mortality rates among patients suffering from congestive heart failure (CHF). Utilizing data from the National Health and Nutrition Examination Surveys conducted between 2007 and 2018, we aimed to understand how these two nutrients impact heart health.
Our findings revealed a significant connection between magnesium deficiency and increased risk of death from all causes as well as from heart-related issues. Specifically, patients with a high magnesium depletion score had a 72% higher risk of all-cause mortality and a 71% higher risk of cardiovascular-related mortality.
On the other hand, higher serum vitamin D levels were linked with a lower risk of both all-cause and cardiovascular mortality. This means that maintaining appropriate levels of vitamin D might improve survival rates among CHF patients. Interestingly, we found that patients with low vitamin D levels and high magnesium deficiency faced an alarming risk—over twice that of those with high vitamin D and low magnesium deficiency.
Overall, our study emphasizes the potential benefits of having adequate vitamin D and magnesium levels for improving outcomes in patients with heart failure. This suggests that attention to nutrient intake could play a critical role in supporting heart health and longevity.
Our findings revealed a significant connection between magnesium deficiency and increased risk of death from all causes as well as from heart-related issues. Specifically, patients with a high magnesium depletion score had a 72% higher risk of all-cause mortality and a 71% higher risk of cardiovascular-related mortality.
On the other hand, higher serum vitamin D levels were linked with a lower risk of both all-cause and cardiovascular mortality. This means that maintaining appropriate levels of vitamin D might improve survival rates among CHF patients. Interestingly, we found that patients with low vitamin D levels and high magnesium deficiency faced an alarming risk—over twice that of those with high vitamin D and low magnesium deficiency.
Overall, our study emphasizes the potential benefits of having adequate vitamin D and magnesium levels for improving outcomes in patients with heart failure. This suggests that attention to nutrient intake could play a critical role in supporting heart health and longevity.
8
We conducted a study to explore how vitamin D3, combined with SGLT2 inhibitors, could influence heart health in hypertensive obese patients suffering from obstructive sleep apnea (OSA). This combination therapy was assessed for its effects on various health parameters and the quality of life of the participants.
In our investigation, patients were randomly assigned to receive either Dapagliflozin, vitamin D3, a combination of both, or no treatment at all over 16 weeks. We closely looked at measurements such as weight, blood pressure, blood sugar levels, liver health, and heart function among others.
Our findings were promising, revealing beneficial effects of combining vitamin D3 with SGLT2 inhibitors. Participants who received this combination reported improvements in their cardio-metabolic health and overall quality of life, suggesting a potential new approach to managing heart disease in this specific group of patients.
It is important to note that while this study highlights the synergistic benefits of vitamin D3 and SGLT2 inhibitors, the isolated impact of vitamin D itself on heart disease remains somewhat unclear. This complexity underscores the need for further research to fully understand vitamin D's role in cardiovascular health.
In our investigation, patients were randomly assigned to receive either Dapagliflozin, vitamin D3, a combination of both, or no treatment at all over 16 weeks. We closely looked at measurements such as weight, blood pressure, blood sugar levels, liver health, and heart function among others.
Our findings were promising, revealing beneficial effects of combining vitamin D3 with SGLT2 inhibitors. Participants who received this combination reported improvements in their cardio-metabolic health and overall quality of life, suggesting a potential new approach to managing heart disease in this specific group of patients.
It is important to note that while this study highlights the synergistic benefits of vitamin D3 and SGLT2 inhibitors, the isolated impact of vitamin D itself on heart disease remains somewhat unclear. This complexity underscores the need for further research to fully understand vitamin D's role in cardiovascular health.
7
We investigated the relationship between low vitamin D levels and the severity of heart disease, particularly in women. The study looked at 1,484 patients who suffered from acute myocardial infarction, focusing on how vitamin D deficiency—defined as levels below 20 ng/mL—affects coronary artery disease (CAD).
We found that women generally had lower vitamin D levels than men. Notably, severe cases of CAD were more prevalent in women with vitamin D deficiency compared to those with sufficient levels, indicating a significant connection. Women with both vitamin D deficiency and diabetes mellitus exhibited more than three times the risk of severe heart disease compared to those who did not have either condition. These findings reveal an alarming synergy between low vitamin D levels and diabetes in contributing to serious heart conditions in women.
However, it's crucial to note that this study did not examine the effectiveness of vitamin D treatment itself. Therefore, while we observed associations between deficiency and increased heart disease risk, we cannot deduce that simply correcting vitamin D levels will reduce the risk or severity of CAD. Our insights underline the importance of monitoring vitamin D status, especially in women at risk for heart disease and diabetes.
We found that women generally had lower vitamin D levels than men. Notably, severe cases of CAD were more prevalent in women with vitamin D deficiency compared to those with sufficient levels, indicating a significant connection. Women with both vitamin D deficiency and diabetes mellitus exhibited more than three times the risk of severe heart disease compared to those who did not have either condition. These findings reveal an alarming synergy between low vitamin D levels and diabetes in contributing to serious heart conditions in women.
However, it's crucial to note that this study did not examine the effectiveness of vitamin D treatment itself. Therefore, while we observed associations between deficiency and increased heart disease risk, we cannot deduce that simply correcting vitamin D levels will reduce the risk or severity of CAD. Our insights underline the importance of monitoring vitamin D status, especially in women at risk for heart disease and diabetes.
References
- Vanreusel I, Hens W, Van Craenenbroeck EM, Paelinck BP, Segers VFM, et al. Vitamin D levels correlate with exercise capacity in adults with CHD. Cardiol Young. 2025. 10.1017/S1047951125000526
- Loh HH, Tay SP, Koa AJ, Yong MC, Said A, et al. Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients. J Transl Med. 2025;23:296. 10.1186/s12967-025-06312-w
- Qi H, Zhou Y, Hou HT, Wei JH, He GW, et al. Contributing role and molecular basis of Vitamin D/Vitamin D receptor deficiency in hyperhomocysteinemia-induced cardiac hypertrophy. Biochem Pharmacol. 2025;234:116812. 10.1016/j.bcp.2025.116812
- Haghighatafshar M, Shekasteband B, Firuzyar T, Etemadi Z, Farhoudi F, et al. The Impact of Vitamin D Deficiency on Coronary Artery Disease Severity Based on Myocardial Perfusion Imaging: A Cross-Sectional Study. Iran J Med Sci. 2025;50:31. 10.30476/ijms.2024.101112.3372
- Astani A, Maroofi A, Hekmatimoghaddam S, Sarebanhassanabadi M, Safari F. Sirtuin 1 mediates the pro-survival effects of vitamin D in angiotensin II-induced hypertrophy of H9c2 cardiomyoblasts. Mol Biol Rep. 2024;52:96. 10.1007/s11033-024-10168-6
- Algül E, Özbeyaz NB, Şahan HF, Aydinyilmaz F, Erdoğan A, et al. Low vitamin D levels are associated with impaired diastolic function in patients with acute coronary syndrome. Minerva Cardiol Angiol. 2025;73:57. 10.23736/S2724-5683.24.06515-3
- Sun L, Du J. Magnesium status, serum vitamin D concentration and mortality among congestive heart failure patients: a cohort study from NHANES 2007-2018. Magnes Res. 2024;37:61. 10.1684/mrh.2024.0528
- Aleksova A, Janjusevic M, Pani B, Hiche C, Chicco A, et al. The Co-Existence of Hypovitaminosis D and Diabetes Mellitus Triples the Incidence of Severe Coronary Artery Disease in Women. J Clin Med. 2024;13. 10.3390/jcm13226792
